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Paper
Title

Evaluation of The Effect of Crocin on Behavioral, Motor and Cognitive Functions in Autistic Model Rats

Year: 1398
COI: NIMED03_121
Language: EnglishView: 354
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Fatemeh Rezamohammadi - Student Research Committee, Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Mehrnoush Rahmani - Student Research Committee, Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abbas Ali Vafaei - Student Research Committee, Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abbas Ali Taherian - Student Research Committee, Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Abstract:

Previous studies have shown that autism, or self-preservation, is a type of neurodegenerative disorder commonly seen in social communication and relations. Previous studies suggested that crocin, as the main combination of saffron, had potent antioxidanteffects and probably had a beneficial effect on autismrelated disorders. Accordingly, the aim of this study was to determine the effect of crocin on behavioral, motor and cognitive functions in autistic model rats in experimental rats. Materials and Methods: In this experimental study, valproic acid was injected on day 12 of pregnancy (when the embryonic development of the neural tube occurs) for induction of autism. Also, some groups were injected with crocin (15 And 30 mg / kg body weight) or vehicle were placed intraperitoneally.On the other hand, all mice were tested on days 30 and 60 (Maze Plus, Hot plate, Rotarod, Open field, Morris Water Maze). Results: Data analysis showed that injection of valproic acid can cause behavioral disorders including decreased social interactions, increased repetitive behaviors, increased pain tolerance thresholds, increased anxiety, decreased behavioral behaviors, reduced balance power and motor learning, and cognitive change in rat infants undergo postnatal evaluation, which is usually done on days 30 and 60, and the administration of crocin can significantly modify these abnormalities. (P<0.05) .Conclusion: These findings showed that crocin can modify behavioral,motor and cognitive functions in autistic model mice and may be effective in the pharmacological treatment of autistic dysfunction

Paper COI Code

This Paper COI Code is NIMED03_121. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/951914/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Rezamohammadi, Fatemeh and Rahmani, Mehrnoush and Vafaei, Abbas Ali and Taherian, Abbas Ali,1398,Evaluation of The Effect of Crocin on Behavioral, Motor and Cognitive Functions in Autistic Model Rats,Third International Nervous System Inflammatory Conference and Third Student Neuroscience Festival,Mashhad,https://civilica.com/doc/951914

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Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 893
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