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Paper
Title

Effect of Sex Difference in HPA Axis Response to Involuntary Moderate Exercise in PTSD Rats

Year: 1398
COI: NIMED03_184
Language: EnglishView: 298
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Sakineh Shafia - Department of Immunology Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Ali Rashidy-Pour - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abbas Ali Vafaei - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Simin Ehsani - Department of Immunology Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract:

Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma and have special symptoms for example: inability to extinguish fear memories, increase behavioral anxiety, disturbance in HPA axis and BDNF decrease. Moderate response rates and side effects to common treatment indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. Interaction between stress, fear and sex are related to activity in HPA axis, and Stress response is moderated by these factors. This regulation is damaged in PTSD. Response to stress is not to same in male and female. In female this axis have faster responses and release more stress hormones than male. Estrogen and testosterone control HPA axis response. Testosterone inhibit HPA axis response and estrogen increasing activity in this axis. The present study investigated theeffects of moderate treadmill exercise on HPA axis dysfunction in PTSD rats. Materials and Methods: We used to single prolonged stress (SPS) model as animal model for PTSD. The rats divided two groups; SPS and Sham group. Rats in SPS group were exposed to (restraint for 2 h, forced swimming for 20 min and ether anesthesia) and were then kept undisturbed for 14 days. After that, SPS rats were subjected to moderate treadmill running (4 weeks, 5 days per week) and the followed by HPA axis activity in male and female PTSD rats by DST. Results: SPS male and female rats exhibited enhanced negative feedback on the HPA axis following a dexamethasone suppression test.Conclusion:Moderate treadmill exercise alleviated the SPS-induced alterations in HPA axis inhibition and there was no significant difference between male and female rats response to exercise.

Paper COI Code

This Paper COI Code is NIMED03_184. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/951974/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Shafia, Sakineh and Rashidy-Pour, Ali and Vafaei, Abbas Ali and Ehsani, Simin,1398,Effect of Sex Difference in HPA Axis Response to Involuntary Moderate Exercise in PTSD Rats,Third International Nervous System Inflammatory Conference and Third Student Neuroscience Festival,Mashhad,https://civilica.com/doc/951974

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Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 1,987
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