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Effect of Sex Difference in HPA Axis Response to Involuntary Moderate Exercise in PTSD Rats

تعداد صفحات: 1 | تعداد نمایش خلاصه: 143 | نظرات: 0
سال انتشار: 1398
کد COI Paper: NIMED03_184
زبان Paper: Englishglish
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مشخصات نویسندگان Paper Effect of Sex Difference in HPA Axis Response to Involuntary Moderate Exercise in PTSD Rats

Sakineh Shafia - Department of Immunology Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Ali Rashidy-Pour - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abbas Ali Vafaei - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Simin Ehsani - Department of Immunology Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

چکیده Paper:

Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma and have special symptoms for example: inability to extinguish fear memories, increase behavioral anxiety, disturbance in HPA axis and BDNF decrease. Moderate response rates and side effects to common treatment indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. Interaction between stress, fear and sex are related to activity in HPA axis, and Stress response is moderated by these factors. This regulation is damaged in PTSD. Response to stress is not to same in male and female. In female this axis have faster responses and release more stress hormones than male. Estrogen and testosterone control HPA axis response. Testosterone inhibit HPA axis response and estrogen increasing activity in this axis. The present study investigated theeffects of moderate treadmill exercise on HPA axis dysfunction in PTSD rats. Materials and Methods: We used to single prolonged stress (SPS) model as animal model for PTSD. The rats divided two groups; SPS and Sham group. Rats in SPS group were exposed to (restraint for 2 h, forced swimming for 20 min and ether anesthesia) and were then kept undisturbed for 14 days. After that, SPS rats were subjected to moderate treadmill running (4 weeks, 5 days per week) and the followed by HPA axis activity in male and female PTSD rats by DST. Results: SPS male and female rats exhibited enhanced negative feedback on the HPA axis following a dexamethasone suppression test.Conclusion:Moderate treadmill exercise alleviated the SPS-induced alterations in HPA axis inhibition and there was no significant difference between male and female rats response to exercise.

کد Paper/لینک ثابت به این Paper

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https://civilica.com/doc/951974/

کد COI Paper: NIMED03_184

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undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Effect of Sex Difference in HPA Axis Response to Involuntary Moderate Exercise in PTSD Rats,سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب,Mashhad,,,https://civilica.com/doc/951974

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Shafia, Sakineh؛ Ali Rashidy-Pour و Abbas Ali Vafaei و Simin Ehsani)
برای بار دوم به بعد: (1398, Shafia؛ Rashidy-Pour و Vafaei و Ehsani)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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