The Effect of Air-Pollution on MS Patient s Relapses

Multiple sclerosis is an autoimmune chronic inflammatory demyelinating disease of the central nervous system. Its prevalence and incidence rate has increased globally, consequently in Iran. Although some studies implicated the association between MS and concentration of vitamin D, sunlight, lifestyle, smoking, genetic predisposition (HLA allele), infections(EBV), climate and seasonal changes and number of siblings,triggers of MS relapsing are still essentially unknown. In this study the effect of air-pollution on MS relapsing s investigated. Materials and Methods: (air-pollution, Multiple Sclerosis and relapsing) were searched as keywords in (Pub med, Google scholar, Scopus)databases. Results: 100 articles were found at last 12 of them were selected (2011-2018). These studies reveals that the air-pollution ingredients such as Fe, Cu, Cd, PM10, SO2, NOX, Pb, Ni, Mn, Zn and O3 especially in industrial areas are associated with CNS oxidative stress,neuro-inflammation, neuronal damaging, endothelial cell damage in the cerebral vasculature and blood brain barrier. In addition, they can have various effects by their interactions in multi-pollutant models, for instance different effects by season changing. Conclusion: Theexposure to the air-pollution in particular PM10 could have direct relation with MS relapsing. Carrying out such researches in this field to making suitable models describing prognosis of air-pollution effect on MS can even reach to triggers of MS relapsing and decrease itscomplications.