The Effect of Ghrelin Intrahippocampal Injection on Motor Balance, Memory in Rat
Publish place: Third International Nervous System Inflammatory Conference and Third Student Neuroscience Festival
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
View: 350
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
NIMED03_221
تاریخ نمایه سازی: 7 آبان 1398
Abstract:
Today, memory impairment in neurodegenerative diseases Like Alzheimer, is one of the major dilemmas. Ghrelin is a peptide hormone thatis synthesized by hypothalamus, pituitary, and some other tissues. This hormone may affect learning and especially motion memory in the hippocampus. The aim of this study was to investigate the effects of ghrelin intrahippocampal injection otor coordination, memory. Materials and Methods: 36 male rats were divided into 6 groups, including control, saline, ghrelin (0.3, 1.5 or 3 nmol) and citicoline. All groups were trained in the rotarod test for 3 times to each rat. Results: the result showed that dosage 3 nmol of ghrelin significantly can be improved motor coordination and memory in competition to citycholine (P<0.0001). Conclusion: It seems that ghrelin could be used to treat memorydisorders such as Alzheimer’s
Authors
Vahideh Sahraiian
Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran
Homayoun Khazali
Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran