MS14 a Marine-Herbal Medicine, an Immunosuppressive Drug in Multiple Sclerosis: A Narrative Review

Multiple sclerosis (MS) is an autoimmune disorder that distinguished by destruction of myelin sheath in the central nervous system. This damage disturbs the ability of parts of the CNS to communicate, resulting in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems, such as loss of sensitivity or changes in sensation, muscle weakness, blurred vision, very pronouncedreflexes, muscle spasms, or difficulty in moving;difficulties with coordination and balance (ataxia); problems with speech or swallowing, visual problems (nystagmus, optic neuritis or double vision), feeling tired, acute or chronic pain, and bladder and bowel difficulties. There are multiple drugs that suppress the progression of MS like: interferon beta-1a, interferon beta-1b, glatiramer acetate, mitoxantrone, dimethylfumarate, alemtuzumab, and ocrelizumab. Not only are there lots of side effects for people using these drugs but also these kinds of drugs are not cost benefit for economically poor patients. Herbal drugs can be a helpful alternative for curing MS patients.Among several herbal drugs, MS14 is an inexepensive and easy-access one that include: 90% Penaeus latisculatus, 5% Apium graveolens and 5% Hypericum perforatum. This Iranian marine-herbal drug has antiinflammatory and immunomodulatory activities, which shows a significant effect on animal model with Experimental Allergic Encephalomyelitis (EAE). EAE is a demyelinating model that mimics many features of MS. In mice with EAE the level of Interlukine-6 (IL- 6) is higher than normal mice. Several researches has shown that enrichment of mice’s food with MS14 is effective in decreasing the level of IL-6. Conclusion: Further research based on animal model of EAE and role of MS14 in patient with MS will be likely useful.