The Role of Long Non-Coding RNA in Regulation and Development of Function in Neurodegenerative Diseases

Long noncoding RNAs (lncRNAs) also participate in a wide array of subcellular processes; have gained widespread attention in recent yearsas a potentially new and crucial layer of biological regulation. It was investigated by numerical research that, lncRNAs refer to a group of noncoding RNAs (ncRNAs) more than 200 nucleotides in length in eukaryotic cells lncRNAs including the formation and function of cellular organelles which regulate the expression of the genes related to central nervous system (CNS). Neurodegenerative diseases areassociated with multiple clinical manifestations, brain pathologies, and health consequences. Increasing evidence has suggested that lncRNAs are involved in the pathogenesis of neurodegenerative diseases. This review summarizes data on lncRNAs expression in the central nervous system (CNS) and neurodegenerative diseases and focuses on the role of some specific lncRNAs, which may provide new insights into our