The Effect of Expression TWEAK Membrane Protein for Neuroinflammation in Neurological Diseases

The tumor necrosis factor like weak inducer of apoptosis (TWEAK) is a Protein of cell membrane in inflammation, proliferation, angiogenesisand cell death. Although different studies have been conducted around this marker, the exact effect of TWEAK on neuroinflammation continues to be discussed. In this study we aim to evaluate the effect of TWEAK expression on neuroinflammation in neurologicaldisease. In this review we searched PubMed, Cochrane and ISC database during April 2019 with tumor necrosis factor like weak inducer of apoptosis (TWEAK), Nervous system disease and inflammation keywords. We obtained 21, 14 and 6 articles from PubMed, Cochraneand ISC databases respectively. At first step we exclude 21 articles by investigating the title and 13 articles by reviewing the abstracts. 2 articles were duplicated, so at the end we include 5 article in our study. In this study, 5 clinical trials were reviewer. In 4 studies, there is asignificant relationship between neuroinflammation and TWEAK expression. So that the neuroinflammation in neurological diseases like MS, increased of TWEAK has been observed. The finding has been shown microglia in subpial cortical lesions and of macrophages in the inflamed meninges expresses TWEAK (50% and 80%_90%, respectively) indicates. But at the one study they can not see significant difference in the TWEAK protein levels and neurological diseases. Conclusions: According to the results, Evidence suggests TWEAK is involved in the development of neuroinflammation in neurological diseases But Further studies on the expression of inflammatory cytokines can be a goodroute for future research and Even a way to treat neurological diseases.