Inhibition C1q Proteins: A Way to Control Seizures in Epilepsy Inhibition C1q Proteins
Publish place: Third International Nervous System Inflammatory Conference and Third Student Neuroscience Festival
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NIMED03_316
تاریخ نمایه سازی: 7 آبان 1398
Abstract:
Epilepsy is a kind of chronic neurological disorders characterized by seizures. About 1% of the world’s population have epilepsy and almost 80% of cases occure in developing countries. The C1q protein, the initiation protein of classical complement cascade associated with the immune inflammatory response, has been shown to be important in synaptic pruning through actions involving microglia. C1q and other protein supplements concentrate in synaptic regions where synaptic structures become weak or lost due to the activity of phagocytosis by microglials. Studies on rats show significant increase in c1q and its components (C3, ic3b) in epileptic mouse compared and the most increasewas observed in the level of ic3b, which was significantly associated with the frequency of seizures. Conclusion: Inconclusion, it seems that level of C1q protein increases in seizure disorders, thus we can control the inflammation by inhibition the protein and prevent the progression of disease, however it needs to do more researches on different animal models and human.
Authors
Elahe Safari
Student Research Committee, Faculty of Nursery and Midwifery, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Pouya Ghaderi
Student Research Committee, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Zeinab Boostani
Student Research Committee, Faculty of Nursery and Midwifery, Mashhad Branch, Islamic Azad University, Mashhad, Iran