Bioinformatics Prediction and Introducting of Some Targeting Mirrnas of EPM2A and NHLRC1 Genes in Lafora Progressive Myoclonus Epilepsy Patients and Draw Networks of Interactions Bethween miRNAsand Genes

Epilepsy is a common neurological disorder with freguent seizures and decreased mental function. One of its types is Lafora disease (LD) ismutation in genes EPM2A and NHLRC1 that it leads to the accumulation of in soluble glycogen deposits in the neurons. Vrious ways have been derised to treat Epilepsy that one of them is the use of miRNAs in terfernce small. MiRNAs intracts translation and actually expressingEpilepsy genes with the effection the transcription (mRNA) of these genes. Methods: Sites NCBI, SID. ir, PubMed were used to obtain information about the genes involved in the disease. In this study to evaluat the single-nucleutide poiymorphism (SNP) in the genesand miRNA related with them were used miRBAS, MIRNASNP databases. Correlation between genes and miRNAs and also bioinformatics review by software miRWALK2, the intereonnection network between genes and microcon trollers was selected. Result: Research onthe sites indicated that these EPM2A and NHLRC1 genes are most importand those are involve in Epilepsy. These genes, respectively, order the production of proteins called Lafora and Malin. These protein have been considered in a complex but incomplete pathway described in the memory of glycogen metabolism. Reviews is shown that the transcription of these genes in 3′UTR site consists of two SNP with high freguensy. In EPM2A rs11966789 A⁄C with has-miR-3943 and in NHLRC1 rs11966789 C/G with has-miR-186-5P couble by high affinity. Thesignal patways of DAVID and Kegg site showed that miRNAs of this research have in terfering effects on some of the cancerous genes such as K-Ras, MDM2. Conclusion: The setaps grid is drown between the set of genes and miRNAs wich are potentially involved in epileptic seizures, can clavity the role of miRNAs in the development and progression of the disease.