Comparison Between Misoprostol and Extra Amniotic Salin Infusion (EASI) for Cervical Ripening

Introduction:Cervical ripening is very important in successful labor induction. There are several mechanical and medical methods for cervical ripening. This study aimed to compare the efficacy of Misoprostol and EASI for a successful labor induction. Materials and Methods: In this double-blind clinical trial, 130 singleton term parturients (age 18-45) with unripe cervix were randomly allocated into two groups: Misoprostol and EASI. First group received Misoprostol (25 μg/vaginal) and the second group had foly catheter. All groups were compared for induction time to the active phase of labor, induction time to the delivery, dilatation changes during the first 6 hours after intervention, Type of delivery, Duration of hospitalization, meconium passage and adverse effects of these methods.Findings: Findings show that two groups were matched in terms of age, parity, gestational age, BMI, and initial dilatation and Bishop Score.There was a significant difference between two groups in Bishop Score and cervical dilatation 6 hours after induction which was more in EASI group. (P <0.0001).The interval time between onset of induction and active phase of labor and delivery were significantly, shorter in EASI group. (P <0.0001).Cesarean rate in Misoprostol group was significantly higher than EASI groups. (P<0.026).The rate of fetal distress, placental abruption, and amniotic fluid meconium was significantly higher in misoprostol group (P<0.0001). Hospital length of stay was shorter in EASI group (P<0.0001).Conclusion: EASI seems to be more effective and safer than Misoprostol for cervical ripening. Considering to its availability and lower cost, it is recommended to use for cervical ripening

Keywords:

Misoprostol , EASI , Labor , Induction