The Effect of PRP on Clinical Pregnancy Outcome of Repeated Implantation Failure Patients Referred to Mother Infertility Clinic of Sari City

Background: Platelet rich plasma (PRP) as an outpatient procedure and due to its possible effect in improving homeostasis is becoming to be a popular method in different medical interventions as well as infertility treatment especially repeated implantation failures (RIF). However, its definitive effect on clinical pregnancy outcome is yet to be defined. The aim of this study was to assess the PRP effect on clinical pregnancy outcome in repeated implantation failure patients referred to Mother infertility clinic of Sari city. Method: In this clinical trial research, 42 RIF patients were recruited based on following inclusion criteria: age, cause of infertility, endometrium thickness, number of days that patients were treated with progesterone, number of transferred embryos, embryos quality and embryo transfer quality. The women divided in to two groups: PRP treated (n=22) and non PRP treated (n=20). In PRP treated group, platelet number was measured before and after process where it was promoted at least 4 times after process then injected into uterine cavity 48 hours before embryo transfer. Clinical pregnancy was recorded as result. Data normality was assessed in SPSS software version 25 using Kolmogorov smirnov test and Mann whitney test was used to assess significant difference in p<0.5.Result and Conclusion: No significant difference was observed between two groups in this study. Although there are some evidence in which the positive effect of PRP on clinical pregnancy outcome has been shown in RIF patients, however, no significant effect was observed for PRP effect in this study. Furthermore, the same experiment with a larger sample size is suggested

Keywords:

Infertility , Pregnancy , RIF , PRP.