Anti-apoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a High-fat Diet
Publish place: Journal of Nutrition, Fasting and Health، Vol: 7، Issue: 3
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNFH-7-3_004
تاریخ نمایه سازی: 13 آبان 1398
Abstract:
Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the anti-apoptotic effects of interval and continued training and crocin on diabetic rats. Methods: In this study, 49 adult rats aged eight weeks with diabetes inducaed by a high-fat diet and venous injection of streptozotocin were randomly assigned to seven groups, including high-intensity interval training (HIIT), low-intensity continued training (LICT), HIIT with crocin consumption, LICT with crocin consumption, crocin consumption, sham, and control. The animals in the HIIT and LICT groups ran on a treadmill three sessions per week for eight weeks at the intensity of 80-85% and 50-55% of the maximum speed, respectively. The animals in the crocin consumption groups received 25 mg/kg of crocin weekly for eight weeks. Results: HIIT and LICT could significantly increase Bcl-2 and decrease Bax and p53, as well as the ratio of Bax and Bcl-2 (P≤0.05). In addition, crocin consumption could significantly increase Bcl-2 and decrease Bax (P≤0.05). Training with crocin consumption had interactive effects on the increase of Bcl-2 and decrease of p53 and ratio of Bax to Bcl-2 (P≤0.05). Conclusion: According to the results, continued and interval training along with the consumption of crocin exerted interactive anti-apoptotic effects on the rats with diabetes induced by a high- fat diet.
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Authors
Ali Moradi
Department of Sport Physiology, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran
Seyed Ali Hosseini
Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Masoud Nikbakht
Department of Sport Physiology, University of Ahwaz, Ahwaz, Iran
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