Masoumeh Soleimani - Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, Arak University, ۳۸۱۵۶-۸-۸۳۴۹, Arak, Iran.Institute of Nanosciences and Nanotechnology, Arak University, Arak, Iran
Khalil Faghihi - Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Faculty of Science, Arak University, ۳۸۱۵۶-۸-۸۳۴۹, Arak, Iran.Institute of Nanosciences and Nanotechnology, Arak University, Arak, Iran

In this work, new magnetic molecularly imprinted polymers based on multiwalled carbon nanotubes (MMWNTs-MIPs) were synthesized with specific selectivity to ketoconazole (KTZ) as antifungal drug. Firstly, N-(4-carboxy Phenyl) trimellitimide diisosyanate (NTDI), was prepared from reaction of Trimellitic anhydride (1), 4-amino benzoic acid (2) in two steps. Then, methacrylic acid was functionalized by β-cyclodextrin and diisosyanate (MAA-NTDIS-β-CD). MAA- NTDIS-β-CD were used as a functional monomer, ketoconazole as a template, ethylene glycol dimethacrylate (EGDMA) as cross–linking agent and 2,2´- azobisisobu-tyronitrile (AIBN) as initiator. The synthetic compound was characterized by Field Emission Scanning Electron Microscopy (FESEM) techniques, X-ray diffraction (XRD), vibrating sample magnetometer (VSM), Brunauer-Emmett-Teller (BET) and Fourier transform infrared spectroscopy (FTIR). The effect of parameters such as solution pH, contact time, temperature and initial concentrations in controlled release of ketoconazole using MMWCNTs-MIP have been estimated. Batch mode adsorption experiment was carried out to investigate the specific adsorption kinetics of the MMWCNTs-MIP. The MMWCNTs-MIP shown good affinity with a maximum adsorption capacity of 49.26 mol g−1and exceptional selectivity toward KTZ