A New Approach in Advanced Wound Care by Replacement of Chemical Antibacterial Agents With Natural Herbal Drug Extracts in a Nano Wound Dressing

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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NSCEI09_159

تاریخ نمایه سازی: 19 آبان 1398

Abstract:

Wounds are one of the most important issues in wound treatment that negatively affects the quality of life and their proper treatment has been very much considered. Delay in wound healing, especially wounds caused by diseases such as diabetes, obesity and cancer, is one of the key issues that are currently being addressed by scientific researches. As the protective layers of skin during the injury get damaged the microbial and bacterial agents invade the wound area and it became infected. For resolving this problem chemical antibacterial agents such as Silver, Iodine, Tetracycline Hydrochloride and other chemical agents are loaded into the matrix of wound dressings. But these chemicals have side effects and environmentally are not healthy and show some poisonous effects. The purpose of this study was to evaluate antibacterial activity of natural antibacterial agents such as herbal drug extracts by loading them into matrix of wound dressing.To do this, a typical nano wound dressing is made by electrospinning of a FDA approved material like Cellulose Acetate. Therefore different concentrations of this compound were tested to achieve an electrospinable solution and then regarding the total volume of solution a partial volume of a typical antimicrobial herbal drug extract like Thyme was added into the solution and the final solution was electrospun. Antibacterial test and other invitro analysis showed that this new wound dressing had a proper antibacterial activity against the common bacteria‟s like Staphylococcus aureus and Escherichia coli. morphological analysis showed that this fiber wound dressing had a nano structure. Therefore this can be concluded that loading antibacterial herbal drug extract into the matrix of wound dressing can be a good substitution for chemical compounds.

Authors

H Farahani

Department of Engineering, Arak University, Arak, ۳۸۴۸۱۷۷۵۸۴, Iran

A BARATI

Department of Engineering, Arak University, Arak, ۳۸۴۸۱۷۷۵۸۴, Iran

M Arjmandzadegan

Department of Medical Science, Arak University of Medical Science, Arak, Iran

E Vatankhah

Department o f Engineering And New Technologies, Shahid Beheshti University, Tehran, Iran