An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of theTongue: A Preliminary Study

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
View: 282

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

SRMMED22_343

تاریخ نمایه سازی: 19 آبان 1398

Abstract:

Background and objective: Since oral cancer is one of the causes of mortality, the use of materials or methods that can reduce cancer or prevent its progression has particular importance. Aim of the study was to evaluate the antitumor effects of Iranian propolis on dysplastic changes of oral mucosa in rats. Materials and Methods: This study was experimental study and performed on 28 Wistar male rats. They were divided into four groups of seven rats. The Group 1 received: 0.5% 7,12-Dimethylbenz[a]anthracene (DMBA), the Group 2: 0.5% DMBA and 100 mg/kg propolis, the Group 3: 0.5% DMBA and 200 mg/kg propolis and the Group 4: 0.5% DMBA and 400 mg/kg propolis. DMBA in all groups was administered topically (brush) and propolis was injected intraperitoneally. DMBA was brushed twice on the lingual dorsum three times a week for 20 weeks. Propolis injection just every other day and in the days after DMBA was administered for 20 weeks. Rats were sacrificed and histological examinations were performed on tongue specimen. Data were analyzed by SPSS21. Findings: Result showed that by increasing dose of propolis; the degree of dysplasia decreases. As in the control group, dysplastic cells were reached to the middle third of the epithelium while in Groups 2 and 3, which were received propolis 100 mg/kg and 200 mg/kg; atypical cells were seen in the basal region only. In Group 4, which received 400 mg/kg of propolis, epithelial dysplasia was not observed in most cases. The difference was a significant between the control and each groups in terms of severity of dysplasia Conclusion: The results of this study showed Propolis can reduce the degree of dysplasia in doses 100 mg/kg, 200 mg/kg, and 400 mg/kg compared to control (Group 1). propolis can dose-dependently prevent DMBA-induced dysplasia of the oral mucosa in animal model

Authors

Alireza Ebrahimpour

Student, Department of Dentistry, Faculty of Dentistry, Student Research Committee, Mazandaran University of Medical Sciences, Mazandaran, Iran

Maedeh Salehi

Assistant Professor, Department of Oral and Maxillofacial Medicine, Dental School, Mazandaran University, Sari, Iran.

Tahereh Molania

Assistant Professor, Department of Oral and Maxillofacial Medicine, Dental School, Mazandaran University, Sari, Iran.