Mohammad-Hossein Lookzadeh - Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hamidreza Mohammadi - Student Research Committee, Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh Emambakhshsani - Student Research Committee, Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Elahe Jafari Abeshoori - Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Background: Apnea of prematurity is often found in preterm neonates with gestational age less than 34-37 weeks or birth weight less than 1000 grams. Methods: This Randomized Clinical Trial study was conducted on 80 ptemature neonates (less than 34 weeks) from the 1 / 11 / 2017 to 1 / 11 / 2018 in the NICU at Shahid Sadoughi Hospital in Yazd. The neonates experience more than one episode of apnea in 24 hours, with episodes of apnea requiring a bag and ventilating mask. The University s Ethics Committee approved this study and we received the IR code. IRU.MEDICINE.REC.1397.78 Results: In this study, preterm neonates were admitted to the NICU and were randomly divided into two treatment groups which were treated with caffeine or aminophylline. There was a significant difference between in terms of respiratory status between the two groups. Conclusion: There was no significant difference in complications such as the incidence of tachycardia, seizure, hypoglycemia, crying more than one hour, GI intolerance and Sleep disorders among groups.

aminophylline, caffeine, apnea, prematurity