Alireza Khademi - PhD of exercise physiology, Department of Sport Sciences, Nahavand University, Nahavand, Iran.
Asghar Tofighi - Associate professor of exercise physiology, Faculty of Sport Sciences, Department of exercise physiology and corrective movements, Urmia University, Urmia, Iran.
Javad Tolouei Azar - Assistant professor of exercise physiology, Faculty of Sport Sciences, Department of exercise physiology and corrective movements, Urmia University, Urmia, Iran.

Objective: The current study aimed at exploring the effect of 8- week Sub maximal aerobic exercises on main blood hemostasis factors such as, t-PA, PAI-1, Plasminogen, Fibrinogen, D-dimer, PT and PTT in obese low-mobility women.Methods: In current semi- experimental study, 20 women (25-30 years) with low mobility and BMI> 30 kg/m2 voluntarily participated and randomly assigned in two control (without exercise intervention) and aerobic (8 weeks: 10 minutes warm-up, 30-45 minutes sub-maximal aerobic with 60-85 of HR max, and 5 minutes cool down) groups. Blood sampling was measured, one day before the first exercise session and 6 to 48 hours after the last exercise session. Data were analyzed by Pair wise T- test and Independent T- test. P < 0.05 was considered the significance level. Results: The mean of t-PA, PAI-1, Plasminogen, Fibrinogen, D-dimer, and PT increased in the aerobic group (p<0.05). But, PTT decreased significantly (p < 0.05).There was no significant difference in main fibrinolysis and coagulation factors in control group (p> 0.05). There was significant difference between aerobic and control groups after 8 weeks exercise in above factors (p<0.05). Conclusions: The current study suggested that submaximal aerobic exercise can modulate the most of blood hemostasis factors. Aerobic exercises with an intensity more than 50% of HR max and duration of above one hour can improve body mass index and then can control the balance of fibrinolysis and coagulation factors.

Submaximal aerobic exercise, Coagulation Factors, Fibrinolysis Factors, Obesity, Low-Mobility.