Carbohydrate quantity and quality affect the risk of endometrial cancer: a systematic review and dose-response meta-analysis

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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تاریخ نمایه سازی: 25 آبان 1398


Objective: Data on the association of glycemic index (GI) and glycemic load (GL) with risk of endometrial cancer up to 2012 have been summarized in a meta-analysis.Methods: The online databases were searched for relevant publications up to May 2018. Overall, 8 prospective cohort and 5 case-control studies were included in the systematic review and meta-analysis. Two reviewers independently screened literature according to the inclusion and exclusion criteria. Results: Subgroup analysis revealed a significant positive association between dietary intake of total carbohydrate and risk of endometrial cancer after combining estimates from 3 prospective cohort studies with ≥10 years’ duration of follow-up (Combined effect size: 1.29, 95% CI: 1.09-1.53, P = 0.003) and when 3 prospective cohort studies with sample size of ≥50,000 participants were combined (Combined effect size: 1.24, 95% CI: 1.08-1.43, P = 0.002). In addition, a non-linear dose-response relationship was found in this regard after considering estimates from prospective cohort studies (Pnonlinearity = 0.002). Combining effect sizes from case-control studies showed a significant positive association between GI and risk of endometrial cancer; such that in linear dose-response analysis, a 10 unit increase in GI was associated with 4% greater risk of endometrial cancer. However, this association was not significant in prospective cohort studies (P > 0.50).Conclusions: Although dietary intake of total carbohydrate, GI and GL were not significantly associated with risk of developing endometrial cancer, we did find positive association in some subgroups. We found a significant positive non-linear association of GI and GL with risk of endometrial cancer.


Mehdi Sadeghian

Department of Nutrition, School of Paramedicine, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

Alireza Sadeghi

Students Scientific Center, Tehran University of Medical Sciences, Tehran, Iran Morteza Nasiri, Department of Operating Room Nursing, School of Paramedicine, Qom University of Medical Sciences, Qom

Jamal Rahmani

Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Omid Sadeghi

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran