Synthesis of MOF [Zn2 (1,4 bdc)2 (dabco)]n as a control and Drug delivery

Metal-organic framework (MOF) make up an emerging class of porous crystalline materials that consist of multI topic organic linkers and inorganic nodes. In recent years, MOFs have attracted considerable attention for their potential applications in many areas such as gas storage, separation, catalysis, optics, photonic, ion exchange, molecular array, biomedicine, sensing and drug delivery(1). In the present study synthesis procedure, the porous MOF [zn2(1,4 bdc)2 (dabco)]n was prepared via solvothermal . The zn2+ ion was used as a connector, 1,4-diazabicyclo[2,2,2] octane (dabco) as a bridging ligand, and 1,4 benzene dicarboxylic acid (H2 bdc) as a chelating ligand.in a typical reaction, Zn(OAc)2.2H2O , bdc and dabco were added to DMF. The reactant were sealed and stirred for 72h.The reaction mixture was then filtered. The withe crystal were washed with DMF to remove any metal and ligand remained, and dried in a vacuum. Powder X-ray diffraction (PXRD) of sample was measured, which proved its crystalline structure. The IR absorption spectra of sample were recorded in the range of 400-4000 cm-1 with KBr pellets. The produced drug-loaded MOF [cox/zn2(1,4 bdc)2 (dabco)]n was then studied as a drug delivery system. Also the presence of drug was confirmed in the MOF by, XRD patterns, FTIR spectra and TGA(2). Release profiles of drug, approximately with 5 mg of samples loaded was suspended in 5mg of PBS. Release drug was gently and maximum release was in 28h. Quantification of the drug in solution was performed by Uv spectrophotometr using quartz cuvette.[1,2]