Mojdeh Nakhaei, - School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Kamran Akhbari - School of Chemistry, College of Science, University of Tehran, Tehran, Iran.

Metal-Organic Frameworks (MOFs) are known as porous coordination polymers (PCPs) which are compounds constructed from the self-assembly of metal ions or metal clusters and organic linkers [1]. Their high porosity, large surface area and tunable shape are some of the attractive properties of MOFs [2]. MOFs have three-dimensional lattices that can form a web-like structure around microbes, therefore making them effective from all angles. Because of these features, MOFs have the potential for investigation as antibacterial agents [3].Zn4O (BDC) 3) MOF-5) and [Zn2(BDC)2(H2O)2(DMF)2]n (MOF-2) are two MOFs with same reagents but different formulas and structures. The structure of MOF-5 is derived from a simple cubic six-connected net in two stages: the nodes (vertices) of the net are replaced by clusters of secondary building units; second, the links (edges) of the net are replaced by finite rods ( struts ) of BDC molecules. The core of the cluster consists of a single O atom bonded to four Zn atoms, forming a regular Zn4O tetrahedron. Each edge of each Zn tetrahedron is then capped by a CO2 group to form a Zn4 (O)(CO2)6 cluster [4]. MOF-2 is a 2D (4,4) layered framework consisting of paddle-wheel Zn2(COO)4 SBUs which are bridged by BDC2- linkers [5]. It is interesting to study antibacterial activity of these two MOFs and compare their antibacterial activities based on their structures. Thus, these two MOFs were synthesized by same method but different ratio of reagants. Then their structures were characterized by FT-IR, PXRD, TG-DTA and SEM analysis. Finally antibacterial activity of them was studied and compared against gram-positive (Staphylococcus aureus) and gram- negative (Escherichia coli) bacterias.