Investigation of anti-bacterial property of Fe-MIL88(NH2) and MIL-53(Al)

Increasing antibiotic resistance of microorganisms is one of the major societal challenges today and great efforts have been devoted to combat or mitigate the huge dependence on conventional antibiotics by finding alternative antimicrobial treatments. The extraordinary resistance to conventional antibiotic treatments particularly of biofilms grown on solid substrates not only in the medical area (surgeon’s tools, implants) but also in a number of technical applications (underwater optics, ship hulls) and has driven research towards the development of novel coatings with superior antimicrobial properties Metal–organic frameworks (MOFs) are highly ordered structures composed of metal centers and organic linker molecules. The possibility to combine multiple functionalities within one framework makes MOFs an ideal system for designing a periodic arrangement of functional molecular subunits.Fe-MIL-88NH2 was synthesized using 2-aminoterephthalic acid and FeCl3.6H2O as the precursors. FeCl3.6H2O and of 2-aminoterephthalic acid were dissolved in DMF, and then acetic acid was added to the solution. The mixed solution was placed in an oil bath at 120 ˚C and after cooling to room temperature, the particles were isolated by centrifugation and washed with hot ethanol to remove the extra reactants. Finally, the brownish crystal sediment was dried at a gentle temperature in the oven. MIL-53(Al) was synthesized using Al(NO3)3.9H2O and terephthalic acid were dissolved in deionized water and placed in a thermal furnace. A soft white sediment was separated by centrifugation, which was then washed with deionized water twice and dried at room temperature In his paper, we investigated about anti-bacterial, anti-oxidan and anticancer properties of Fe-MIL88(NH2) for the first time. Fe-MIL-88(NH2) synthesized from therephtalic acid and FeCl3.6H2O in presence of DMF in oil bath. MIL-53(Al) also synthesized from therephtalic acid and Al(NO3).9H2O in presence of water in furnace.Results shows that anti-bacterial activity of this compound upon both E.Coli and Pseudomonas stains is stronger than tetracycline and kanamycin antibiotic.