Synthesis and characterization of platinum compounds with ferrocenyl ligand

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
View: 345

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

IICC21_107

تاریخ نمایه سازی: 5 آذر 1398

Abstract:

Platinum complexes are one of the most important compounds in cancer research and therapy. They target DNA molecules in cancerous cells and prevent these molecules from transcription and replication and thus result in cancer cell death. On the other hand, compounds having ferrocenyl moieties are widely used in several drugs including antiproliferative and antimalaria agents [1]; by combining these two promising compounds, platinum core and ferrocenyl moiety, we expect to build a stronger and more flexible antiproliferative drug [2]. In this project, we try to synthesis and investigate properties of a new series of platinum complexes with coordinated ferrocenyl imine ligand. We started from the ferrocene and it was transformed to its aldehyde and then to imine derivatives, finally combined with Pt(Me)2(dmso)2 and Pt(Cl)2(dmso)2 precursors (Scheme. 1). For biologic investigations of the new cyclometalated and monocoordinated platinum complexes, the Ligand-DNA binding via UV-Vis titration and also docking simulations were studied.The NMR spectra show formation of cyclometalated Pt(Me)(imine)(dmso) and monocoordinated Pt(Cl)2(imine)(dmso) complexes. Experimental data from UV-Vis titration and docking simulations are in good agreement. In conclusion, some of the new Platinum complexes with coordinated / cyclometalated ferrocenyl imine ligand were synthetized. Their structures were identified by NMR spectra. Based on DNA titration and docking simulations, highest docking score to ct-DNA was for cyclometalated Pt(Cl)(imine)(dmso).

Authors

Behnam Habibi Shabestari

Department of Chemistry, Shahid Beheshti University, Evin, Tehran, Iran

Mohsen Golbon Haghighi

Department of Chemistry, Shahid Beheshti University, Evin, Tehran, Iran