Synthesis, Characterization, and X-ray crystal structure of new Cu(II) complex with N-(thiazole-2-yl) picolinamide (L) and CuO nanoparticles as New catalysts in CuAAC reaction and antibacterial studies

Several attempts proved that Cu2+ can catalyze several mechanisms such as cycloaddition reactions between azide and alkyne (a typical click reaction) as well as other types of click reaction. In this case, applying Cu2+ nanoparticles to catalyze the specific click reaction in association with carboxamide-based ligands would be a strategic approach to design and implement a highly-efficient catalyst[1].CuO is one of the most important transition metal oxides due to its captivating properties. It is used in various technological applications such as high critical temperature superconductors, gas sensors, in photoconductive applications, and so on. Recently, it has been used as an antimicrobial agent against various bacterial species. Here we synthesized different sized CuO nanoparticles and explored the size-dependent antibacterial activity of each CuO nanoparticles preparation [2].In this work, five-coordinated copper(II) complex, [Cu(L)2(H2O)].CHCl3, was synthesis by N-(thiazole-2-yl) picolinamide (L) with copper(II) acetate. Respectively, Copper oxide (CuO) nanoparticles have been prepared by thermal decomposition using [Cu(L)2(H2O)].CHCl3 complexes as a new precursor at 600°C for 3h under air atmosphere. The complex was characterized using FT-IR spectroscopy, elemental analyses, and their solid state structures were confirmed by single crystal X-ray diffraction. These nanoparticles were identified by fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetry differential thermal analyses (TGA-DTA).The catalytic activity of the complex and nanoparticles were evaluated in one-pot azide–alkyne cycloaddition (AAC) click reaction in water without need of any additional agent.