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Genetic Variant of GIPR Gene and the Risk of Type 2 Diabetes

تعداد صفحات: 1 | تعداد نمایش خلاصه: 105 | نظرات: 0
سال انتشار: 1398
کد COI Paper: ICEMU05_055
زبان Paper: Englishglish
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مشخصات نویسندگان Paper Genetic Variant of GIPR Gene and the Risk of Type 2 Diabetes

Shahrazad Manavi - Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,
Hamid Reza Aghaei Meybodi - Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran,
Mahdi Afshari - Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran,
Negar Sarhangi - Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Davood Abbasi - Iranian Diabetes Society, Eslamshahr Branch, Iran
Mandana Hasanzad - Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

چکیده Paper:

Introduction: Type 2 diabetes mellitus (T2DM), as a worldwide health problem, is a multifactorial disease that environmental and genetic factors contribute to its pathogenesis. Gastric Inhibitory Polypeptide Receptor (GIPR) is a G-pro receptor which controls the gut hormones and insulin secretion. The present study aimed to investigate the role of GIPR rs1800437 gene variant in T2DM susceptibility.Materials & Methods: 108 confirmed T2D patients and 100 normal controls were recruited in the study. The GIPR rs1800437 SNP was determined by PCR-Restriction Fragment Length Polymorphism (RFLP) assay.Results: A significant difference was not found in genotypes (CC, CG, and GG) frequency of GIPR rs1800437 SNP between T2DM and control groups. Frequencies of GG, GC and CC genotypes among the patients were 38.89%,4.63%and56.48% and in the controls were 26%,1% and 73% respectively. Frequency of C allele among cases was significantly lower than that among controls (p=0.002)(OR=0.51).Conclusion: We observed that patients with type 2 diabetes compared with the normal population had significantly lower frequency of the genotype of rs1800437 polymorphism of GIPR gene.Among diabetic patients no difference was observed between C or G allele carriers regarding their HbA1c therefore presence of this polymorphism cannot affect the results of the treatment.

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https://civilica.com/doc/962184/

کد COI Paper: ICEMU05_055

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undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Genetic Variant of GIPR Gene and the Risk of Type 2 Diabetes,پنجمین همایش بین المللی و هفتمین همایش سراسری تازه های غدد و متابولیسم,Isfahan,,,https://civilica.com/doc/962184

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برای بار اول: (1398, Manavi, Shahrazad؛ Hamid Reza Aghaei Meybodi و Mahdi Afshari و Negar Sarhangi و Davood Abbasi و Mandana Hasanzad)
برای بار دوم به بعد: (1398, Manavi؛ Aghaei Meybodi و Afshari و Sarhangi و Abbasi و Hasanzad)
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