Publisher of Iranian Journals and Conference Proceedings

Please waite ..
CIVILICAWe Respect the Science
Publisher of Iranian Journals and Conference Proceedings
عنوان
Paper

Association Between Common Genetic Polymorphism in MTNR1B and Susceptibility to Type 2 Diabetes Mellitus

تعداد صفحات: 1 | تعداد نمایش خلاصه: 104 | نظرات: 0
سال انتشار: 1398
کد COI Paper: ICEMU05_056
زبان Paper: Englishglish
نسخه کامل Paper در کنفرانس ارائه نشده است و در دسترس نیست.

مشخصات نویسندگان Paper Association Between Common Genetic Polymorphism in MTNR1B and Susceptibility to Type 2 Diabetes Mellitus

Anahita Fakhraei Nasab - Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,
Hamid Reza Aghaei Meybodi - Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Mahdi Afshari - Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran
Negar Sarhangi - Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran,
Davood Abbasi - Iranian Diabetes Society, Eslamshahr Branch, Iran
Mandana Hasanzad - Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran, Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

چکیده Paper:

Introduction: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Any imbalance in melatonin levels can be related to various metabolic disorders. Melatonin and the genetic variants of Melatonin Receptor 1B (MTNR1B) are reported to be associated with T2DM susceptibility. We investigated the association between rs4753426 single nucleotide polymorphisms (SNP) in the MTNR1B gene and the risk of developing T2D in group of Iranian people.Materials & Methods: : In this case-control study 208 individuals were recruited (108 T2DM cases and 100 normal controls). Genomic DNA was isolated from whole blood and genotyping was performed by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR- RFLP).Results:The frequencies of TT , CT and CC genotypes for the T2DM group were 91.67% , 0% and 8.33 % and 56% , 3% and 41% in the control group , respectively . Frequency of C allele among cases was significantly lower than controls (8.33% vs 42.5% respectively, p<0.001). The odds ratio for C allele was 0.12 (p<0.001)Conclusion: We found that patients with type 2 diabetes mellitus had significantly lower frequency of the genotypes of rs4753426 polymorphism of MTNR1B gene compared to normal population. In addition, the allelic investigation showed that carriers of C allele had 88% lower risk of developing diabetes mellitus compared to T allele carriers. Therefore, this allele can be a protective factor against diabetes mellitus. In conclusion, our study showed that rs4753426 polymorphism of MTNR1B gene can be associated with diabetes mellitus.

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/962185/

کد COI Paper: ICEMU05_056

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Association Between Common Genetic Polymorphism in MTNR1B and Susceptibility to Type 2 Diabetes Mellitus,پنجمین همایش بین المللی و هفتمین همایش سراسری تازه های غدد و متابولیسم,Isfahan,,,https://civilica.com/doc/962185

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Fakhraei Nasab, Anahita؛ Hamid Reza Aghaei Meybodi و Mahdi Afshari و Negar Sarhangi و Davood Abbasi و Mandana Hasanzad)
برای بار دوم به بعد: (1398, Fakhraei Nasab؛ Aghaei Meybodi و Afshari و Sarhangi و Abbasi و Hasanzad)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

Research Info Management

Certificate | Report Paper
این Paper در بخشهای موضوعی زیر دسته بندی شده است:
  • علوم پزشکی > دیابت
  • Export Citation info of this Paper to research management softwares

    Share this paper

    WHAT IS COI?

    COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.

    Support