ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

The Cytotoxic Properties and Anticancer Impacts of Zinc oxide Nanoparticles On Human Breast, MCF7 Cell Lines

Year: 1398
COI: CANCER01_023
Language: EnglishView: 323
This Paper With 5 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 5 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Ghasem Rahimi Kalateh Shah Mohammad - Biochemistry Department, Islamic Azad University, Mashhad Branch, Iran
Vahid Pouresmaeil - Biochemistry Department, Islamic Azad University, Mashhad Branch, Iran

Abstract:

Nanotechnology enable us to manipulate the substances at nanoscale level. Metallic nanomaterials such as Zn O nanoparticles synthesized with chemical methods, which has the disadvantage of using deleterious chemicals. Green chemistry allows the design and synthesis of nanoparticles, with reducing or elimination of hazardous materials. One of the important applications of zinc oxide nanoparticles is to use as an antibacterial and anticancer agent. In this study, we synthesized Zn O nanoparticle using Hyssopus officinalis plant extract and evaluate its their cytotoxicity on MCF7 breast cancer cell line. Materials and Methods: The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) cell viability assay was done on MCF7 cell line. Cells were seeded on 96-well plates and incubated for 24 hours. After 24 hours, cells were treated with different concentrations of Zn O nanoparticles (8, 16, 32, 64 and 128 μg / ml) and incubated for next 24, 48 and 72 hours. Then, treatments removed and MTT was added to each well. DMSO was used in order to dissolve insoluble blue crystals and absorbance was read at 570 nm. Results: Results showed that Zn O nanoparticles synthesized in Hyssopus officinalis plant extract are able to inhibit MCF7 cells. However, this inhibition was at low concentrations of Zn O nanoparticles and the values of IC50 (in 24, 48 and 72-hour treatment) respectively was calculated at 16, 10 and 5 μg/ml NPs. Conclusion: Results of this study indicated the inhibitory effects of Zn O nanoparticles synthesized in Hyssopus officinalis plant extract on cancer cells. However, in vitro studies should perform in order to confirm these effects. Finally, these results demonstrate the anticancer potential of Zn O nanoparticles, which could be used as therapeutic agent in cancer therapy.

Keywords:

Paper COI Code

This Paper COI Code is CANCER01_023. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/963407/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Rahimi Kalateh Shah Mohammad, Ghasem and Pouresmaeil, Vahid,1398,The Cytotoxic Properties and Anticancer Impacts of Zinc oxide Nanoparticles On Human Breast, MCF7 Cell Lines,International Conference on Cancer Research 2019,https://civilica.com/doc/963407

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم
این Paper در بخشهای موضوعی زیر دسته بندی شده است:

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: Azad University
Paper count: 9,635
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support