Mehdi Ranjbar - pharmaceutics Research Center,Institute of Neuropharmacology,kerman University of Medical Sciences,Kerman,Iran
payam khazaeli - pharmaceutics Research Center,Institute of Neuropharmacology,kerman University of Medical Sciences,Kerman,Iran
arezou amanatfard - pharmaceutics Research Center,Institute of Neuropharmacology,kerman University of Medical Sciences,Kerman,Iran

Background and Objective: Metal-organic frameworks (MOFs), as nanoporous particulate materials, in the past two decades has shown well-known properties such as desirable pore size, pore shape, large surface areas and the ability to encapsulated compound and drugs [1], MOFs has a wide range applications such as separation , catalysis, chemical sensing [2] and drug delivery [3], MOFs are new class of hybrid crystalline materials networks that are constructed via covalent linkages between metal ions/metal clusters and organic ligands called a linker with high porosity and thermal stability [4].Materials and Methods: In this work, the stoichiometric amount of Zn(OAc)2.2H2O powders as the starting reagent were solved in 15 mL mixed solvent (DMF: ethanol: DI water = 1:1:2), the solution was stirred under vigorous stirring and heat up at 50 °C for 120 min. The synthesized precipitate was obtained, centrifuged, washed several times with DMF and finally dried at at room temperature for 3 days. For synthesis of mixed-linker MOFs (MIXMOFs), at first 2,6-pyridinedicarboxylic and C6H12O6as linkage precursors in molar ratio 1:2 were solved in in molar ratio 2:1:1 (DMF: ethanol: DI water) under vigorous stirring at room temperature.Pruductscharacterized by XRD, SEM, TEM, UV-vis, IR and BET.Findings:The high resolution shape and size of the nanosized materials or nanostructures were investigated by scanning electron microscopy. Observations show that metal organic frameworks have been prepared in with a lot of porosityand there are relatively strong bonds between β-estradiol with double ligands. The particle size obtained with the electron microscopy is in accordance with the data of the X-ray diffraction pattern. To evaluate the thermal stability of nanostructures we used thermal gravimetric analysis (TGA), observations show that thermal behavior of the nanocomposites can be divided into tow separated regions, by increasing the temperature in the first area temperature range 110-130 °C, which is related to the loss of water, the most significant weight loss (mass change: 11.89%) happensConclusion: Zn-MOFs nanocompositescontaining β-estradiol werecharacterized by XRD, SEM, TEM,UV-vis, IR and BET. Total pore volume(p/p0=0.990) of Zn-MOFs nanocomposites estimated 0.046656[cm3g-1] that these structures can use to trapping β-estradiol

β-estradiol, Adsorption, Zn-MOFs,Nanocomposites, Coprecipitation assisted Microwave method