Basal cell carcinoma arising in a Leishmania scar: a case report from Isfahan, Iran

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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DCME02_194

تاریخ نمایه سازی: 19 آذر 1398

Abstract:

Background: Leishmaniasis is a protozoan parasitic disease endemic in different parts of Iran, with three major clinical forms, cutaneous(CL), mucocutaneous (ML) and visceral Leishmaniasis (VL). According to the epidemiological studies, the city of Isfahan is an important area with high CL infection, the disease doesn’t challenging in terms of death or disability, However, in permanent disfiguring scar, Long term period wound healing and also sometimes could be a risk factor for the development of malignant Lesions. Scars in CL are frequently presented as an outcome of the disease at the site of the sand-fly bite some studies suggest that the occurrence of malignancy in site of scars can be exist.Objectives: Here we present a case of basal cell carcinoma (BCC) developing in a Leishmania scar after 44 years, supposing that manifestation of BCC in the current case was triggered by Leishmania parasites and affected by sunlight exposure.Case report: A 53-year-old man presented with the two months history of single Lesion on his nose arising in a broad, flat Leishmania Scar, The patient referred to the Sedigheh Tahereh clinic, Isfahan, Iran and gave a history of having had Leishmaniasis (acute cutaneous form) 44 years ago, at the age of 9 years that resolved with a scar at the same site of the present lesion. He also had a history of sun exposure due to outdoor working. Discussion: The pathogenesis of malignancy in site of chronic scar is not well-known, understood, but there are some hypothesis: scars may have some biochemical changes occurring during wound healing. In fact, diminish blood supply and epidermis’s atrophy can make these scars more susceptible to the damaging effects of ultraviolet radiation, especially in this present case placement of the lesion in an area of sun exposure on previously scarred skin is thought to be a risk factor.Conclusion: Leishmaniasis further studies in these such cases with appropriate methods and experiments are recommended to carefully determine these challenging hypotheses.

Authors

Zahra Mollabashi

Ph.D. Molecular and cellular biology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Zabihollah Shahmoradi

Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Hanieh Sharifian-Koupaiee

Ph.D. microbiology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran