اثرات درمانی کوئرستین در مدل سپسیس القایی با لیپوپلی ساکارید در دوز پایین در سگ و مقایسه آن با هیدروکورتیزون

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJVM-13-4_005

تاریخ نمایه سازی: 20 آذر 1398

Abstract:

BACKGROUND: Canine low-dose sepsis model provides a reliable setting to study innovative drugs. Li- popolysaccharides (LPS), a major constituent of bacterial outer membrane, have been demonstrated to play a critical role in the initiation of pathogenesis. Lipopolysaccharide-induced sepsis has been extensively studied in laboratory animals; but its importance has mainly remained unknown in dogs. OBJECTIVES: The aim of the present survey was to examine the effectiveness of quercetin, along with hydrocortisone on clinical and hematological alterations, and organ failure (liver and heart) in low-dose lipo- polysaccharide-induced canine sepsis model. METHODS: For this purpose, fifteen clinically healthy mixed dogs were randomly divided into three equal groups. Lipopolysaccharide (0.1 μg/kg, IV) was injected to dogs in group A (control). Group B was similar to group A, but quercetin bolus (2 mg/kg, IV, once) was injected 40 minutes after LPS injection. Group C was similar to group B; however, hydrocortisone bolus (2 mg/kg, IV, once) was administered instead of quercetin. Serum levels of glucose, total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatine kinase isoenzyme muscle/brain (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin I (cTn-I) concentration were measured by commercial kits. RESULTS: In control group, red blood cells (RBCs), hemoglobin (Hb), and hematocrit (HCT) significant-  ly decreased and serum activities of AST, ALP, LDH, CK-MB, and plasma cTn-I significantly increased (P<0.05). RBCs, Hb, and HCT significantly increased in quercetin group, compared with hydrocortisone and control groups (P<0.05). Quercetin group significantly decreased LDH, CK-MB, and cTn-I compared with hydrocortisone and control groups (P<0.05). Quercetin significantly decreased AST in comparison to control group and ALP in comparison to hydrocortisone group, also (P<0.05). CONCLUSIONS: These results suggest that quercetin protects RBCs in the early stages of sepsis and de- creases organs dysfunction (heart and liver), therefore it has a positive influence on sepsis and may be more effective than routine corticosteroid (hydrocortisone) therapy.

Authors

Alale Soltanian

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Bahman Mosallanejad

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Mohammad Razi Jalali

Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran

Hosein Najafzadeh

Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

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  • Afshari, M., Rahimmalek, M., Miroliaei, M. (2018) Variation in polyphenolic ...
  • Asgary, S., Naderi, G.H., Askari, M.S. (2005) Pro- tective effect ...
  • Balk,   R.A.   (2014)   Systemic   inflammatory re- ...
  • sponse syndrome (SIRS). Virulence, 5(1),  20- ...
  • https://doi.   org/10.4161/viru.27135. ...
  • Baskurt, O.K., Gelmont, D., Meiselman, H.J. (1998) Red blood cell ...
  • Ceylan-Isik, A.F., Zhao, P., Zhang, B., Xiao, X., Su, ...
  • G. and Ren, J. (2010) Cardiac overexpression of metallothionein rescues ...
  • Das, D.K., Chakraborty, A., Sinha, M., Manna, K., Mukherjee, D., ...
  • De David, C., Rodrigues,  G.,  Bona,  S.,  Meur- er, L., ...
  • De Vries, F., Leuschner, J., Jilma, B., Derhaschnig, ...
  • U. (2013) Establishment of a low dose canine endotoxemia model ...
  • Egert, S., Wolffram, S., Bosy-Westphal, A., Boesch-Saadatmandi, C., Wagner, A.E., ...
  • Geraets, L., Moonen, H., Brauers, K., Wouters, E.F.,   Bast,  A.,   ...
  • etary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary ...
  • Goyette, R.E., Key, N.S., Ely, E.W. (2004) Hema- tologic changes ...
  • s-2004-860979.  PMID: 16088507. ...
  • Ikizler, M., Erkasap, N., Dernek, S., Kural, T., Kaygisiz, Z. ...
  • Javadi, B., Sahebkar, A. (2017) Natural products with anti-inflammatory and ...
  • Kitagawa, S., Sakamoto, H., Tano, H. (2004) In- hibitory effects ...
  • Landry, D.W., Oliver, J.A. (2001) The pathogene- sis of vasodilatory ...
  • Liao, Y., Lin, J. (2015) Quercetin intraperitoneal ad- ministration ameliorates ...
  • 5.07.015. PMID: 26209141. ...
  • Penalva, R., Gonzalez-Navarro, C.J., Gamazo, C., Esparza, I., Irache, J.M. ...
  • 1016/j.nano.2016.08.033. PMID: 27615118. ...
  • Punithavathi, V.R., Stanely Mainzen Prince, P. (2011) The cardioprotective effects ...
  • proterenol-induced myocardial infarcted rats. J Biochem Mol Toxicol, 25(1), 28-40. ...
  • Reinboth, M., Wolffram, S., Abraham, G., Unge- mach, F.R., Cermak, ...
  • Rochwerg, B., Oczkowski, S.J., Siemieniuk, R.A.C., Agoritsas, T., Belley-Cote, E., ...
  • CCM.0000000000003262.  PMID:  29979221. ...
  • Shapiro, H., Lev, S., Cohen, J., Singer P. (2009) Polyphenols ...
  • Valentova, K., Sima, P., Rybkova, Z., Krizan, J., Malachova, K., ...
  • Vasquez-Garzon, V.R., Arellanes-Robledo, J., Garcia-Roman, R., Aparicio-Rautista, D.I., Villa-Trevino, S. ...
  • Virginia, D.V., Owen, H., Poapolathep, A., Mario, ...
  • G. (2017) Natural substances as new potential strategies for the ...
  • Volbeda, M., Wetterslev, J., Gluud, C., Zijlstra, J.G., van der ...
  • ysis. Intensive Care Med, 41(7), 1220-1234. https://doi. org/ 10.1007/s00134-015-3899-6. PMID: ...
  • Wan,  Y.,   Tang,  M.H.,  Chen,  X.C.,  Chen,   L.J., ...
  • Wei, Y.Q., Wang, Y.S. (2014) Inhibitory ef-  fect of liposomal ...
  • Yang, H., Song, Y., Liang, Y.N., Li, R. (2018) Quer- ...
  • MSM.909259.  PMID: 29987270. ...
  • Yao, Z., Gu, Y., Zhang, Q., Liu, L., Meng, G., ...
  • H., Xia, Y., Bao, X., Shi, H., Sun, S., Wang, ...
  • Zhou, M., Jia, Q., Wu, Y., Song, K., Gao, W., ...
  • Zhang, J., Shi, L., Xu, X., Huang, S., Lu, B., ...
  • نمایش کامل مراجع