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Production, quality control, and bio-distribution of 141Ce-EDTMP as a potential bone pain palliation agent

تعداد صفحات: 1 | تعداد نمایش خلاصه: 67 | نظرات: 0
سال انتشار: 1397
کد COI Paper: RINMMICMED22_051
زبان Paper: Englishglish
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مشخصات نویسندگان Paper Production, quality control, and bio-distribution of 141Ce-EDTMP as a potential bone pain palliation agent

Fatemeh Soltani - Department of Medical Radiation Engineering, Science & Research Branch, Islamic Azad University, Tehran, Iran
Simindokht Shirvani Arani - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Tehran, Iran
Mahdi Sadeghi - Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Samira Heidary - Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Ali Bahrami Samani - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Tehran, Iran
Kamal Yavari - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Tehran, Iran

چکیده Paper:

Background: The purpose of this present was to introduce 141Ce-EDTMP as a novel potential pain palliative agent to patients suffering from disseminated skeletal metastases and diagnostic imaging radioisotope as well. Cerium-141 [T1/2=32.501 days, Eβ (max)=0.580 (29.8%) and 0.435(70.2%) MeV, Eγ=145.44 (48.2%) keV] possesses suitable properties for use in palliative therapy of bone metastases.Methods: Ethylene diamine tetramethylene phosphonic acid (EDTMP) was synthesized and radiolabeled with 141Ce. Complexation parameters were optimized to achieve maximum yields (> 99%). The radiochemical purity of 141Ce-EDTMP was evaluated by radio-thin layer chromatography. The stability of the complex that monitored for one week at room temperature was > 99%. Biodistribution of the complexes carried out in wild-type rats.Results: The images showed high uptake of complex in bone after 72h. The percentage injected dose per gram of tissue (%ID/g) for each organ was calculated. The blood clearance was rapid.Conclusion: The properties of produced 141Ce-EDTMP suggest a new agent to overcome metastatic bone pains.

کلیدواژه ها:

Cerium-141, Bone pain palliative, EDTMP, Radiopharmaceutical, Therapy

کد Paper/لینک ثابت به این Paper

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https://civilica.com/doc/968648/

کد COI Paper: RINMMICMED22_051

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در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1397,Production, quality control, and bio-distribution of 141Ce-EDTMP as a potential bone pain palliation agent,بیست و دومین همایش سالیانه پزشکی هسته ای ایران,Yazd,,,https://civilica.com/doc/968648

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برای بار اول: (1397, Soltani, Fatemeh؛ Simindokht Shirvani Arani و Mahdi Sadeghi و Samira Heidary و Ali Bahrami Samani و Kamal Yavari)
برای بار دوم به بعد: (1397, Soltani؛ Shirvani Arani و Sadeghi و Heidary و Bahrami Samani و Yavari)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.
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