The Effect of Intravitreal Recombinant Tissue Plasminogen Activator Injection on Diabetic Tractional Fibrovascular Membranes: Proposed Criteria using Optical Coherence Tomography
Publish place: xxix annual congress of the iranian society of ophthalmology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
View: 400
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ACSOMED29_019
تاریخ نمایه سازی: 30 آذر 1398
Abstract:
Purpose: o evaluate the effect of intravitreal recombinant tissue plasminogen activator (rTPA) on diabetic tractional fibrovascular membranes (FVM) using the proposed optical coherence tomography (OCT) based measurement criteria. Methods: This prospective, interventional case series enrolled eyes that were candidates for vitrectomy. OCT images were obtained to study attached–detached retinal borders at baseline and on- week post-intravitreal rTPA injection using the follow-up scan protocols. Two independent graders assessed retinal detachment (RD) height, FVM height, FVM thickness, retinal thickness at the site of membrane attachment and release of retina-membrane touch point. Results: Nine eyes from nine individuals were included. Assessment of RD height, FVM height, FVM thickness and retinal thickness at touch point were feasible in 8/9 (88%), 7/9 (77%), 8/9 (88%) and 5/9 (55%) of eyes, respectively. There was an excellent agreement between the two graders in all of measurements (all ICC> 0.93). Release of retina-membrane touch point was not observed in any eyes. No statistically significant change was found in any of the measured parameters. Conclusion: Our proposed OCT-based measurement system in assessing diabetic FVM was reliable and feasible. We did not find any significant change in the status of diabetic FVM, one-week after intravitreal rTPA injection, using OCT-based measurements.
Authors
Khalil Ghasemi Falavarjani
Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Pasha Anvari,
Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Mohamadhassan Dehghan,
Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Saber Molaei,
Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Pegah Kazemi
Eye Research Center and Eye Department, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran