The Association Between the Transforming Growth Factor Beta-1 -509C> T Gene Polymorphism and Primary Open Angle Glaucoma in North Eastern Iran
Publish place: xxix annual congress of the iranian society of ophthalmology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ACSOMED29_101
تاریخ نمایه سازی: 30 آذر 1398
Abstract:
Purpose: Glaucoma is a common cause of irreversible blindness. Transforming growth factor beta-1(TGF- β1) is the main isoform of TGF-β superfamily in the eye. Overexpression of TGF-β1 is shown to be related with the glaucoma. Studies have shown that the presence of mutant T allele of TGF-β1 -509C> T polymorphism (rs1800469) is associated with increased gene expression. So, in present study, association of the TGF-β1- 509C> T gene polymorphism and primary open angle glaucoma (POAG) in patients from north east of Iran was investigated. Methods: A case-control study was conducted on 112 POAG patients and 112 control participants. TGF-β1- 509C> T genotyping was done by PCR-restriction fragment length polymorphism (PCR-RFLP) method using Bsu36I restriction enzyme. Moreover, cup to disk ratio(CDR), intraocular pressure (IOP) and visual acuity (VA) were measured. The obtained results were statistically analyzed. Results: The highest frequency of genotype in the control group was related to CC genotype (44.6%), but the heterozygous CT genotype (45.6%) was observed as the highest frequency of genotypes in patient group (P value: 0.022, OR for TT genotype: 2.54 CI95% for OR: 1.22, 5.27). Also, the frequency of the T mutant allele showed a significant difference between case and control groups (P value: 0.005, OR: 1.73 CI95% for OR: 1.18, 2.53). Conclusion: In conclusion, a significant association was seen between TGF-β1 -509C> T gene polymorphism and POAG disease and inheritance of mutant T allele is considered to be a risk factor for glaucoma in patients living in North Eastern part of Iran.
Authors
Akbar Derakhshan,
Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences,Mashhad, Iran.
Jalil Tavakkol Afshari
Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences,Mashhad, Iran.
Javad Sadeghi Allah Abadi
Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences,Mashhad, Iran.
Amin Reza Nikpoor,
Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences,Mashhad, Iran.
Saeed Shokoohi Rad
Eye research center, Khatam-Al-Anbia eye hospital, Mashhad University of Medical Sciences,Mashhad, Iran.