Synthesis of tetrahydro-5H-thiazolo[3,2-a]pyridine-6-carbohydrazide derivatives as new hydropyridone compounds

Synthesis of functionalized (E)-N -(benzylidene)-7-(aryl)-8-nitro-5-oxo-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyridine-6-carbohydrazide derivatives by acid hydrolysis of (E)-5-amino-N′-benzylidene-8-nitro-7-aryl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6-carbohydrazide derivatives in acidic media is described. The main advantages of this method are good to high yields, mild reaction conditions, simple work-up, easy purification and preparation of potentially bioactive compounds

Keywords:

2-pyridone , thiazolo pyridine , acid hydrolysis.