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PRENATAL METHAMPHETAMINE EXPOSURE COULD CAUSE CHRONIC ABNORMALITIES IN EPIGENOME ASSOCIATED WITH AUTISTIC LIKE BEHAVIOR, AN EXTENDED FOLLOW UP STUDY

تعداد صفحات: 2 | تعداد نمایش خلاصه: 84 | نظرات: 0
سال انتشار: 1398
کد COI Paper: KAMED13_018
زبان Paper: Englishglish
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مشخصات نویسندگان Paper PRENATAL METHAMPHETAMINE EXPOSURE COULD CAUSE CHRONIC ABNORMALITIES IN EPIGENOME ASSOCIATED WITH AUTISTIC LIKE BEHAVIOR, AN EXTENDED FOLLOW UP STUDY

Arvin Haghighatfard - Department of Genetics, Tehran medical sciences Branch,Islamic Azad university, Tehran, Iran
Soha Seifollahi - department of Genetics, Tehran medical sciences Branch,Islamic Azad university, Tehran, Iran
Niloofar Rahmani - department of Genetics, Tehran medical sciences Branch,Islamic Azad university, Tehran, Iran
Rojin Ghannad zadeh - department of Genetics, Tehran medical sciences Branch,Islamic Azad university, Tehran, Iran
Pegah Rajabi - department of Genetics, Tehran medical sciences Branch,Islamic Azad university, Tehran, Iran
Fateme Khanchi - 6. Department of genetics, Tehran Medical sciences branch,Islamic Azad university, Tehran, Iran

چکیده Paper:

Background and Aim : High rate of methamphetamine abuse among young adults and women of childbearing age makes it imperative to clarify the long-term effects of Methamphetamine exposure on the offspring. Present study aimed to assess the effects of parental Methamphetamine exposure in epigenetic programming and gene expression of children along with brain functions.Methods : All subjects were recruited before birth and sampling were conducted from day of birth in each six month until children get two years old. Hundred and fifty children with methamphetamine dependent mothers (with methamphetamine abuse during pregnancy) and 150 unrelated children with normal non psychiatric mothers were selected. Blood sampling and DNA and RNA extraction was operated. Genome-wide DNA methylation profiling of peripheral blood leukocytes conducted by using the Illumina Methylation 450K BeadChip platform. Genome expression profiling was conducted by using Affymetrix GeneChip Human Genome U133 plus 2.0 Array Platform. Gene expression data was confirmed by Real time PCR. Also electroencephalography performed for two years old children with 64 channel Biosemi EEG system.Results : Results showed seven CpG loci identified that their DNA methylation was significantly different in children with Meth-dependent mothers versus children with normal mothers. Pathway analysis revealed that hypermethylated CpG loci associated with Meth-dependent mothers were related to transcriptional regulation (P = 0.0004), mitogen-activated protein kinase (Mapk) signaling pathway (P = 0.002), synaptogenesis (P = 0.0004) and lymphocytes T maturation (P = 0.0006). Gene expression profiling showed mRNA level alteration in children with Meth-dependent mothers in 78 genes. Most of these genes were involved in synaptogenesis, neural plasticity, bioenergetic and immune system.Significant stronger activation in higher frequencies detected in frontal, parietal, and occipital regions of meth exposed children vs. normals. Conclusion : It seems that Methamphetamine abuse before and during the pregnancy period may affect epigenetic and expression profile of children and these changes could be remain years after birth. Both affected genes and neuroimaging changes are strongly similar to pattern of autistic children.findings may shed lights on molecular and neuronal effects of prenatal methamphetamine exposure as well as other pediatric developmental disorders.

کلیدواژه ها:

Methamphetamine , prenatal, electroencephalography,epigenome

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/974823/

کد COI Paper: KAMED13_018

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,PRENATAL METHAMPHETAMINE EXPOSURE COULD CAUSE CHRONIC ABNORMALITIES IN EPIGENOME ASSOCIATED WITH AUTISTIC LIKE BEHAVIOR, AN EXTENDED FOLLOW UP STUDY,سیزدهمین کنگره بین المللی دانش اعتیاد,Tehran,,,https://civilica.com/doc/974823

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Haghighatfard, Arvin؛ Soha Seifollahi و Niloofar Rahmani و Rojin Ghannad zadeh و Pegah Rajabi و Fateme Khanchi)
برای بار دوم به بعد: (1398, Haghighatfard؛ Seifollahi و Rahmani و Ghannad zadeh و Rajabi و Khanchi)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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نوع مرکز: azad university
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