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EXPRESSION STUDY OF CREB GENE FAMILY IN METHAMPHETAMINE ABUSERS WITH AND WITHOUT PSYCHOSIS

تعداد صفحات: 1 | تعداد نمایش خلاصه: 82 | نظرات: 0
سال انتشار: 1398
کد COI Paper: KAMED13_033
زبان Paper: Englishglish
نسخه کامل Paper در کنفرانس ارائه نشده است و در دسترس نیست.

مشخصات نویسندگان Paper EXPRESSION STUDY OF CREB GENE FAMILY IN METHAMPHETAMINE ABUSERS WITH AND WITHOUT PSYCHOSIS

Mohammad Darzian Rostami - Department of biology, North Tehran branch,Islamic Azad university, Tehran, Iran
Arvin Haghighatfard - Department of genetic, Tehran Medical sciences branch,Islamic Azad university, Tehran, Iran
Esfandiar Azad marzabadi - Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences
Mitra Salehi - Department of biology, North Tehran branch,Islamic Azad university, Tehran, Iran
Parviz Pakzad - Department of biology, North Tehran branch,Islamic Azad university, Tehran, Iran

چکیده Paper:

Background and Aim : Methamphetamine abuse alter behavioral characteristic which in some cases includes psychotic symptoms. Mechanisms of psychosis in meth-induced psychosis and its similarities and differences with psychosis in individuals with psychiatric disorders are not completely clarified. Present study aimed to shed lights in role of cAMP response element-binding protein (CREB) a family of transcription factors that are involved in memory and cognition, in methamphetamine abuse and meth-induced psychosis.Methods : Three groups including 20 methamphetamine dependents, 20 meth-induced psychosis and 20 normal non psychiatric subjects were selected. Blood sampling and RNA extraction was operated. Gene expression of CREB family including CREB1, CREB2, CREB3 and CREB4 was evaluated by Real time PCR.Results : Results indicate different expression profiles in Methamphetamine abusers, Meth-induced psychosis in compare with control subjects. Significant over expression of CREB1 and significant down expression of CREB2, CREB3, and CREB4 were detected in both methamphetamine abusers and meth-induced psychosis in compare with normal subjects. mRNA level of CREB1 were over expressed in meth-induced psychosis versus methamphetamine dependent without psychosis. Conclusion : Results suggest that methamphetamine abuse may deregulate genes which are involved in memory formation. In addition CREB family especially CREB1 could be related to meth induced psychosis that is different with psychosis in patients with psychiatric disorders and could considering as biomarkers for meth-psychoses

کلیدواژه ها:

methamphetamine; meth-induced psychosis; CREB

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/974836/

کد COI Paper: KAMED13_033

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در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,EXPRESSION STUDY OF CREB GENE FAMILY IN METHAMPHETAMINE ABUSERS WITH AND WITHOUT PSYCHOSIS,سیزدهمین کنگره بین المللی دانش اعتیاد,Tehran,,,https://civilica.com/doc/974836

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Darzian Rostami, Mohammad؛ Arvin Haghighatfard و Esfandiar Azad marzabadi و Mitra Salehi و Parviz Pakzad)
برای بار دوم به بعد: (1398, Darzian Rostami؛ Haghighatfard و Azad marzabadi و Salehi و Pakzad)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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نوع مرکز: azad university
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