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Paper

ALTERATION OF BDNF AND 5HTTPLR GENES MRNA LEVEL IN OPIUM ABUSERS AFTER TAPER OFF TREATMENT

تعداد صفحات: 1 | تعداد نمایش خلاصه: 74 | نظرات: 0
سال انتشار: 1398
کد COI Paper: KAMED13_035
زبان Paper: Englishglish
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مشخصات نویسندگان Paper ALTERATION OF BDNF AND 5HTTPLR GENES MRNA LEVEL IN OPIUM ABUSERS AFTER TAPER OFF TREATMENT

Ani Dezhakam - Department of biology, science and research branch,Islamic Azad university, Tehran, Iran
Arvin Haghighatfard - Department of genetics, Tehran Medical sciences branch,Islamic Azad university, Tehran, Iran
Peyman Hassani Abharian - Department of neuroscience, Institute for Cognitive Science Studies, Tehran, Iran
Azade Hekmat - Department of biology, science and research branch,Islamic Azad university, Tehran, Iran

چکیده Paper:

Background and Aim : Opium is the dried latex obtained from the opium poppy. Opium addiction is the most prevalent addiction in Iranian society. During last two decades congress 60 a nongovernmental organization, have been performed a taper off treatment of opium associated with a package of psychological treatments group classes. While the effectiveness of taper off method in opium addiction has been confirmed, molecular mechanisms of this treatment in addicts are not totally clarified. BDNF gene is a brain derived neurotrophic factor which is related to several molecular mechanisms of brain including memory. 5HTTPLR is a transporter of serotonin that is related in decision making process. Methods : In present study mRNA level of BDNF and 5HTTPLR genes in peripheral blood of 20 non-psychiatric persons and 79 opium addicted individuals before and after six months period of taper off treatment examined by using Real Time PCR. Also executive functions including memory and decision making were analyzed in all participants.Results : Results showed significant down expression of BDNF and 5HTTPLR in addict persons vs. non-psychiatric persons. Also significantly increase detected in BDNF (p<0.01) and 5HTTPLR (p<0.01) expression level in addicts after six months of therapy period. Also significant improvement of memory and decision making were revealed in addicts after therapy and these improvements were correlated with expression level of BDNF and 5HTTPLR. Conclusion : Findings revealed effect of opium abuse and taper off treatment on expression of BDNF and 5HTTPLR. Also association of BDNF mRNA level with psychological states of addict s individuals detected. Results of present study may help to better understanding from molecular and neurological mechanisms of opium and taper off treatment. Also present BDNF and 5HTTPLR as potential markers for screening the effectiveness of different kinds of addiction treatment.

کلیدواژه ها:

taper off treatment, opium, congress 60, BDNF, 5HTTPLR

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/974838/

کد COI Paper: KAMED13_035

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,ALTERATION OF BDNF AND 5HTTPLR GENES MRNA LEVEL IN OPIUM ABUSERS AFTER TAPER OFF TREATMENT,سیزدهمین کنگره بین المللی دانش اعتیاد,Tehran,,,https://civilica.com/doc/974838

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Dezhakam, Ani؛ Arvin Haghighatfard و Peyman Hassani Abharian و Azade Hekmat)
برای بار دوم به بعد: (1398, Dezhakam؛ Haghighatfard و Hassani Abharian و Hekmat)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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