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THE EFFECT OF DESCURAINIA SOPHIA OIL ON METHAMPHETAMINE INDUCED CELL CYTOTOXICITY AND CELL DEATH IN PC12

تعداد صفحات: 1 | تعداد نمایش خلاصه: 75 | نظرات: 0
سال انتشار: 1398
کد COI Paper: KAMED13_036
زبان Paper: Englishglish
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مشخصات نویسندگان Paper THE EFFECT OF DESCURAINIA SOPHIA OIL ON METHAMPHETAMINE INDUCED CELL CYTOTOXICITY AND CELL DEATH IN PC12

Hossein Zhaleh - Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Moslem Sahraei - Department of Medcinal Plants, Institue of Higher Education, Jaha-e-Daneshgahi, Kermanshah, Iran
Masoumeh Khanahmadi - Department of Medcinal Plants, Institue of Higher Education, Jaha-e-Daneshgahi, Kermanshah, Iran
Rouholah Morad - Department of Chemistry, Kermanshah Branch of ACECR, Kermanshah, Iran
Nastaran Kazemi - Department of Chemistry, Kermanshah Branch of ACECR, Kermanshah, Iran
Komail Amini - Department of Medcinal Plants, Institue of Higher Education, Jaha-e-Daneshgahi, Kermanshah, Iran

چکیده Paper:

Background and Aim : Methamphetamine causes cytotoxicity and apoptosis in different cell lines. It seems that Descurainia Sophia oil, as an East Asian folk herbal drug, can suppress the methamphetamine-induced cell death. In this study, protective effects of Descurainia Sophia oil was followed up in methamphetamine-induced cell cytotoxicity and death in a neuron-like PC12 cell line.Methods : The viability, proliferation, and cytotoxicity of the cells, were assessed by Trypan blue, MTT test, and LDH assay, respectively. TUNEL test was performing to detection of DNA fragmentation and apoptosis. NO level was detected by Griese method.IL-1β, IL-6, INFγ, and TNFα pre-inflammatory cytokines were measured by Rat Kit V-Plex and finally caspase-3 activity was determined by spectrophotometry.Results : Results showed that Descurainia Sophia Oil has cell death-suppressing effects on nerve cells. It enhanced the cell viability and proliferation and also increased the cell cytotoxicity and cell death index in methamphetamine-treated PC12 cells. Also, it suppressed NO production, inflammatory cytokines production and secretion, mitochondrial membrane depolarization, and caspase-3 activity in a dose-dependent manner.Conclusion : We concluded that Descurainia Sophia oil suppresses the methamphetamine-induced cell death in PC12 cell due to reduction of NO production, cytokines synthesis, and inhibition of apoptosis cascade

کلیدواژه ها:

Descurainia Sophia, methamphetamine, PC12 cells

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/974839/

کد COI Paper: KAMED13_036

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,THE EFFECT OF DESCURAINIA SOPHIA OIL ON METHAMPHETAMINE INDUCED CELL CYTOTOXICITY AND CELL DEATH IN PC12,سیزدهمین کنگره بین المللی دانش اعتیاد,Tehran,,,https://civilica.com/doc/974839

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Zhaleh, Hossein؛ Moslem Sahraei و Masoumeh Khanahmadi و Rouholah Morad و Nastaran Kazemi و Komail Amini)
برای بار دوم به بعد: (1398, Zhaleh؛ Sahraei و Khanahmadi و Morad و Kazemi و Amini)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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