UNUSUAL ROUTE OF BUPRENORPHINE ADMINISTRATION: AN ALTERNATIVE APPROACH FOR BYPASSING DRUG ADVERSE REACTIONS
Publish place: 13th annual international addiction science congress
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
KAMED13_338
تاریخ نمایه سازی: 10 دی 1398
Abstract:
Background and Aim : Tramadol abuse is a critical and growing health concern in Asia. In Iran, tramadol abuse arises most commonly as a result of self-medicating that leads to tramadol dependence. Buprenorphine, a partial agonist of mu opioid receptors approved for the treatment of tramadol dependence, is administered sublingually due to its extensive first-pass metabolism and resulting low oral bioavailability. A 50-year-old man presenting with tramadol dependence after self-medicating for chronic low back pain experienced adverse reactions to a minimal dosage (0.8 mg) of sublingual buprenorphine. He was treated successfully with a modified protocol comprised of swallowing sublingual tablets (0.2 mg/day initially, which increased to 0.2 mg every 12 hours during maintenance therapy). This unusual case suggests that swallowing buprenorphine sublingual tablets may prevent adverse effects and reduce the rate of treatment dropout.
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Authors
Azadeh Nazari
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Shahram Naderi Mazjin
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mansour Shamsipour
Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran