Association of a genetic variant in the angiopoietin-like protein 4 gene with metabolic syndrome

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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GCMED08_053

تاریخ نمایه سازی: 10 دی 1398

Abstract:

Background and Aim : Metabolic syndrome (MetS) is characterized by a clustering of cardiovascular risk factors that include: abdominal obesity, dyslipidemia, hypertension and glucose intolerance. Angiopoietin-like protein 4 (ANGPTL4) is a circulating peptide that is an inhibitor of lipoprotein lipase, a key enzyme in lipid metabolism. The objective of this study was to investigate the association of ANGPTL4 gene variants (E40K) with fasting serum triglyceride levels and with cardiovascular risk factors, that included the presence of MetS in 817 subjects recruited from the Mashhad stroke and heart Atherosclerosis Disorders (MASHAD) cohort Study.Methods : ANGPTL4 genotypes were determined using a TaqMan genotyping based real time PCR method. The association of the genetic variant with the risk of metabolic syndrome and its relationship with lipid profile were determined. Results : The frequency of GG, GA and AA genotypes were 96.9, 2.7 and 0.4% in individuals with MetS, and 78.8, 20.8, 0.4%, in those without MetS. The GA genotype of the rs116843064 polymorphism was associated with a lower risk for MetS (e.g., OR in Codominant genetic model: 0.14, 95% CI: (0.06–0.33), p < 0.0001). Subject with an A allele had a higher risk for MetS (OR: 6.72, 95% CI: (3.05–14.82), p < 0.0001). There was a significant difference in fasted lipid profiles across the genotypes for ANGPTL4. Carriers of the AG genotype had higher levels of serum HDL-cholesterol (HDL-C) and lower TG, compared to the GG homozygotes genotype. Conclusion : The G allele at the rs116843064 polymorphic locus of the ANGPTL4 gene was associated with a lower prevalence of MetS.

Authors

Sara Kharazmi-Khorassani

Mashhad University of Medical Sciences

Jasmin Kharazmi-Khorassani

Mashhad University of Medical Sciences

Zam Rastegar-Moghadam

Mashhad University of Medical Sciences

Sara Samadi

Mashhad University of Medical Sciences

Hamideh Ghazizadeh

Mashhad University of Medical Sciences

Gordon A Ferns

Mashhad University of Medical Sciences