Comparison and comparison of telomerase expression in healthy tissue and breast cancer

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

GCMED08_064

تاریخ نمایه سازی: 10 دی 1398

Abstract:

Background and Aim : in order to differentiate between normal and cancer cells, cancer researchers employ gene expression analysis for diagnostic and therapeutic purpose. Most researches delve more into the subject that compares tumor cell lines with normal one, or compare the tumor tissue of the affected patient with the normal tissue of the non-affected person. But the expression of each gene in each person is unique. In the cell tissues of each individual the gene expression is diverse. For this reason, telomerase gene expression of the normal cell and its adjacent tumor cells, in the person who is affected by the breast cancer, measured and compared.Methods : for this purpose, 45 tumor sample and 45 adjacent normal sample, using Sergey, are collected. Using real time PCR, the mRNA expression of telomerase in tumor samples and tumor margins are assessed.Results : the findings were correspondent with the previous findings. In order to separate tumor from tumor margin, the comparison of telomerase gene expression in tumor cell tissue and its adjacent is suitable. The meaningful statistical analysis of this study confirms our findings.Conclusion : in order to identify and interpret cancerous changes, as the results present, the analysis of gene expression in normal samples together with tumor samples is essential. It is very important to diagnose and manage cancer patients.

Authors

Mohsen Igder

Tabriz university

Zahrasadat Rezvani

Tabriz university

Mohammad Rahmati Yamchi

Tabriz university