Psychopharmacological treatments for post-TBI neuropsychiatric impairment

The pathophysiology of traumatic brain injury (TBI) can be variable. The spectrum of TBI includes concussion, mild, moderate or severe TBI, and disorders of consciousness. Furthermore, the neuropsychological consequences of TBI are also miscellaneous. Patients after a TBI may develop psychiatric symptoms such as anxiety, apathy depression, mania, agitation, irritability, disinhibition, and psychosis. In addition, they may suffer from impaired cognitive domains like as memory, attention, processing speed, language, constructional abilities and executive functioning. These neuropsychiatric sequels of TBI are very important in clinic and can result in persistent disability and malfunction. Psychopharmacological treatment strategies for the mentioned sequels of TBI in the chronic phase are also heterogeneous. In this speech I try to review and evaluate the many proposed psychopharmacological options for TBI-related neuropsychiatric deficits.