Evaluation Of Olfactory Function and Retinal Nerve Fiber Layer Changes In Patients With Parkinson s Disease

Background and Aim : Parkinson s syndrome is one of several heterogeneous disease groups. Researchers are looking for a way to more accurately diagnose this disease. One of the things that was studied was the olfactory function of the disease. Other studies have been done on the changes in the neuronal layer of the retina in Parkinson s patients, but have not yet compared it with other symptoms such as olfactory function. Current research has been conducted to investigate the olfactory function and changes in the neural layer of the retina.Methods : In this cross-sectional with cntrol group study that was performed in Rasoul-e-Akram Hospital in 1397 and 1398, 21 patients with Parkinson s disease and 20 healthy subjects were enrolled in the study. The main variables studied were the score obtained in the olfactory test and OCT. OCT was used to check RNFL. MMSE criteria and also UPDRS were used to assess dementia and severity. The Sniffin Sticks have also been used to collect information on the odors in this study. Finally, the data were entered into the SPSS software and analyzed. All patients were enrolled in the written consent form. At each stage, if the patient was reluctant to participate in the study, he was excluded.Results : :The mean age in the case group was 62.25 ± 10.22 and in the control group it was 59.25 ± 6.68, and there was no significant difference between the two groups in terms of age. Gender abundance was almost equal in the two groups (61.9% of males in the case group compared to 55% in the control group). Regarding the mean left side OCT score in the two groups, it can be concluded that none of the 4 quadrants on the left side between the two case and control groups showed a significant difference. On the right, the results were aligned to the left. In relation to the various parts of the Sniffin Sticks test, which included Identification, Discrimination, Threshold, and TDI, it could be stated that all parts of the olfactory test were significantly different between the control and control groups. (P <0.0001)Conclusion : :People with Parkinson s disease with OCT seem to be unlikely to predict the duration of illness or disease as compared to the control group in this study. But those same people can be distinguished from the control group by the Sniffin Sticks smell test, and in other words, the smell of those who have the disease is disrupted and depressed compared to healthy people, which may be the result of this olfactory disorder for months or years before the manifestation Symptoms of motion sickness have begun and become less severe. It can also be concluded that there was no significant relationship between olfactory disturbances and olfactory tests with changes in the neural layer of the retina.

Keywords:

Parkinson disease , olfactory function , retina