Fingolimod attenuates harmaline-induced passive avoidance memory and motor impairments in a rat model of essential tremor

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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NSCMED08_146

تاریخ نمایه سازی: 15 دی 1398

Abstract:

Background and Aim : Preclinical data suggest that Fingolimod (FTY), a sphingosine-1-phosphate receptor modulator, could be beneficial for treating common neurological disorders, including Parkinson s, MS and epilepsy.Methods : In the current study, the effects of FTY on harmaline-induced motor and cognition impairments were studied in Male Wistar rats. Passive avoidance memory, exploratory, anxiety related behaviors, tremor, and motor function were assessedResults : . The memory impairments observed in harmaline treated rats were reversed somewhat by administration of FTY720. The results showed that FTY could recover the step width, left and right step length, but failed to recuperate the mobility duration. FTY improved the time spent in the wire grip and rotarodConclusion : Results of our study shed light on the beneficial effects of FTY on cognition and motor function a model of essential tremor (ET) and suggest that sphingosine-1-phosphate receptor modulators have a potential neuroprotective profile for the treatment of ET.

Authors

Narjes Dahmardeh

Department of anatomical sciences, afzalipour medical faculty, kerman university of medical sciences, kerman, iran

Majid Asadi Shekaari

Intracellular recording lab, kerman neuroscience research center, neuropharmacology institute, kerman university of medical sciences, kerman, iran

Shokouh Arjmand

Intracellular recording lab, kerman neuroscience research center, neuropharmacology institute, kerman university of medical sciences, kerman, iran