The role of mGluR4 receptors within the nucleus accumbens in the acquisition of morphine-induced conditioned place preference in male rat

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

NSCMED08_156

تاریخ نمایه سازی: 15 دی 1398

Abstract:

Background and Aim : Several studies have shown that glutamate in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). Metabotropic glutamate receptors (mGluRs) in the nucleus accumbens also play an important and key role in the reward pathway. However, the role of different subtypes of these mGluR in different steps of the morphine-induced conditioning place preference is less well known. In the present study we investigated the effect of bilateral intra-accumbal infusion of VU0155041, a specific mGluR4 agonist on the acquisition of morphine induced CPP in male rats.Methods : Male Wistar rats weighing 200-250 g were bilaterally implanted with cannulae above the NAc. VU0155041,at the doses 10,30 and 50 μg / μl was injected bilaterally into the nucleus accumbens during the day of conditioning . Conditioning scores and locomotor activity were recorded by maze router software.Results : The results showed injection of mGluR4 agonist in to the nucleus accumbens dose-dependently decreased morphine-induced conditional locus preference in male rats.Conclusion : There is specificity in the role of different mGluR subtypes in reward pathways which has been discussed in this paper.

Keywords:

Metabotropic glutamate receptor type 4 , morphine , nucleus accumbens , conditioning place preference

Authors

Zahra Ebrahimi Farzad

master of science

Nazanin Kahvandi

master of science