Syringic acid decreased convulsion and memory impairment; and increased anti-oxidant parameters in a PTZ-induced model in rats

Background and Aim : Seizure is an abnormal electrical discharge of a group of brain neurons that temporarily disrupts normal brain function. The brain damage caused by the seizure is a dynamic phase that involves many factors that contribute to the death of the neural cells. one of the impressive factors is oxidative stress. Antioxidant compounds have been extensively investigated as a pharmacological alternatives to prevent epileptogenesis. Syringic acid is a substance that has been mentioned in several articles and studies of its antioxidant properties. The objective of the present study was to investigate the effect of Syringic acid on memory, oxidative stress and PTZ-induced seizure in male rats.Methods : 48 male Wistar rats were divided randomly into six groups: Control; PTZ (50 mg/kg, I.P); SA + PTZ (received SA at doses of 25, 50, 100 mg/kg respectively); PHB+PTZ (received Phenobarbital 80 mg/kg). Syringic acid or normal saline were administered 30 minutes before PTZ-convulsion induction. Immediately after PTZ-injection; latency of Convulsions, Number of Convulsions and racine-convulsion scores were evaluated in thirty minutes. Subsequently, ninety minutes after the seizure, inactive avoidance memory was evaluated. Then; rats were anesthetized, brains were removed. In the next step; MDA and GPX level were measured by ELISA.Results : In this study, the effect of Syringic acid anticonvulsant on delayed parameters at the onset of seizure, racine-convulsion scores and Number of Convulsions was observed. In addition, Syringic acid decreased memory impairment. Biochemical observations showed that the oxidative stress were significantly improved in seizure groups under treatment with SA; which reduced lipid peroxidation and increased GPx level.Conclusion : Based on the results obtained in this study Syringic acid can be effective in controlling Pentylenetetrazol-induced seizures. The beneficial effects of SA may be due to its antioxidant properties.

Keywords:

Syringic acid , Seizure , Pentylenetetrazol , Oxidative stress , Memory , Rat