Association of Serum PON1 as an Antioxidant and Depression and Anxiety in Methamphetamine-Dependent Patients

Background and Aim : Although it has been reported that methamphetamine (MA) induces brain dysfunction, increases levels of oxidative stress and psychiatric symptoms, no study has been conducted to study their correlation in MA-dependent patients. The aim of this study was evaluating the correlation of serum levels of PON1 (an antioxidant), and depression and anxiety state of MA-dependent patient.Methods : Nineteen active MA abusers and 18 control subjects were included in the study. Socio-demographic and Addiction Severity Index (ASI) questionnaires were used to determine medical, drug use and family/social status. Depression, anxiety and stress scale - 21 Items (DASS-21) questionnaire was used for evaluation of their depression, anxiety, and stress. Their blood samples were collected to measure the level of PON1 by the human enzyme-linked immunosorbent assay (ELISA) kit. The data were analyzed using Graph Pad PRISM software.Results : Results showed significantly lower levels of serum PON1and higher levels of depression/anxiety in MA abusers compared to the controls. Data analysis revealed a negative correlation between PON1 level and depression/anxiety state in studied subjects.Conclusion : Our results showed higher levels of depression/anxiety which was associated with lower levels of serum PON1 in the MA-dependent patients. Further studies need to elucidate their roles in the pathophysiology of MA addiction.

Keywords:

Anxiety , Depression , Methamphetamine , PON1 , Antioxidant