Protective effects of Chrysin against neurological deficit, infarct size and cerebral hyperemia after cerebral ischemia/reperfusion injury in rats
Publish place: 8th basic and clinical neuroscience congress
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
View: 296
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
NSCMED08_310
تاریخ نمایه سازی: 15 دی 1398
Abstract:
Background and Aim : Cerebral ischemia/reperfusion injury (I/R) is one of the major causes of neurological deterioration, mortality, and disability worldwide. Chrysin (5,7-dihydroxyflavone) is a well-known member of the flavonoid family with antioxidant and neuroprotective effects. In the present study we aimed to investigate the probable effects of Chrysin (CH) on some physiological parameters including cerebral hyperemia, neurological deficits and infarct size induced by bilateral occlusion of the common carotid arteries and reperfusion in rats.Methods : Adult male Wistar rats (250–300 g) were randomly divided into five groups: and submitted to cerebral I/R or a sham surgery after three-weeks of pretreatment with chrysin (CH; 10, 30 and 100 mg/kg; P.O.) and/or normal saline containing %5 DMSO. Subsequently, sensorimotor scores, local cerebral blood flow, and infarct size were evaluated following I/R.Results : Data showed that pretreatment with chrysin significantly improved sensorimotor signs, and attenuated reactive hyperemia (p < 0.001). Furthermore, chrysin pre-treatment significantly decreased the infarct size (p< 0. 01).Conclusion : This study demonstrates that chrysin may have beneficial effectson some physiological parameters and help recover the brain dysfunction induced by I/R.
Keywords:
Authors
Maryam Khombi Shooshtari
Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Alireza Sarkaki
Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Yaghoob Farbood
Department of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran