Diman Mahdie - Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
Leila Derafshpour - Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran
Abbas Ali Vafaei - Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Ali Rashidy-Pour - Laboratory of Learning and Memory, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Background and Aim : Mother s transient thyroid abnormalities during pregnancy and lactation exhibit behavioral disorders in offspring in adulthood. On the other hand, in offspring, changes in sex hormones have been observed due to changes in thyroid hormones, which can exacerbate these disorders. The beneficial effects of exercise and sex hormones treatment on anxiety are well-known. The present study examined the effects of the combined treatment of treadmill exercise and sex hormones treatment on anxiety-like behaviors and serum sex hormones levels in transient congenital hypothyroid rats.Methods : Hypothyroidism induced by 6-propyl-2-thiouracil by adding to the drinking water from the 6th day of gestation to the 21st postnatal day (PND 21). From PND 28 to 47, 17β-estradiol treatment in female and testosterone in male rat pups began and the rats were forced to run on treadmill for 30min once a day. On PND48, the anxiety-like behaviors of all rats tested.Results : Hypothyroidism induced by 6-propyl-2-thiouracil by adding to the drinking water from the 6th day of gestation to the 21st postnatal day (PND 21). From PND 28 to 47, 17β-estradiol treatment in female and testosterone in male rat pups began and the rats were forced to run on treadmill for 30min once a day. On PND48, the anxiety-like behaviors of all rats tested.Conclusion : These findings showed the developmental hypothyroidism adverse effects in adulthood and it is likely that the effects of various treatments in adulthood will be influenced by the critical periods of Brain development.

transient hypothyroidism, exercise, spatial memory, BDNF, rat, estrogen, testosterone