The negative motivational aspect of morphine withdrawal syndrome changes during light-dark cycle

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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NSCMED08_434

تاریخ نمایه سازی: 15 دی 1398

Abstract:

Background and Aim : In mammals, there is an underlying mechanism that dictates the organism’s biological functions and daily activity schedule, known as circadian rhythms, which play a major role in maintaining steady metabolism, homeostasis and immunity. Investigations have shown that the light-dark cycle can affect the mechanisms associated with reward and addiction so in this study the negative motivational effect of morphine withdrawal syndrome was evaluated during day and night.Methods : Male Wistar rats (250-300 g) were administered 10 mg/kg morphine every 12h, for 10 days (n=20). Control rats received saline with the same protocol (n=20). Thereafter, when they were made dependent on morphine, tested for opioid withdrawal-induced conditioned place aversion and physical symptoms of naloxone-induced withdrawal syndrome during day (8:00-12:00) and night (20:00-24:00).Results : The negative motivational aspect of morphine withdrawal syndrome was more severe during day compare to night.Conclusion : It seems that the effects of withdrawal syndrome are more severe during day and this may consider for detoxification of opiate addicts.

Authors

Fatemeh Rahmati Dehkordi

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Saeed Semnanian

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Hossein Azizi

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran