The effect of Tanacetum polycephalum on rotarod motor performance in the pentylenetetrazol kindled rat

Background and Aim : Epilepsy is a common chronic neurodegenerative disorder disease, it can also, affect motor balance. In this study, the medicinal plant Tanacetum polycephalum, was used to evaluate its effect on motor deficit caused by pentylenetetrazol (PTZ) in the rat.Methods : Twenty-four rats were randomly allocated to 4 groups: control negative under treatment with PTZ (sub-threshold dose 35 mg/kg for one month), control positive under treatment with Phenobarbital (PB-30 mg/kg), and two PTZ groups under treatment with T. polycephalum extract (TPE-50, and -100 mg/kg). Standard rotarod test was used to evaluate motor coordination. Data were analyzed using SPSS.Results : Motor-skill tasks in rotarod test in PTZ group receiving TPE at a dose of 50 and 100 mg/kg was greater than PTZ group. In addition, PB 30 mg/kg significantly attenuates the motor impairments in treated animals.Conclusion : Our results showed that TPE could prevent epilepsy and elevate motor coordination in the PTZ-kindled rats.

Keywords:

Tanacetum polycephalum , Epilepsy , Rotarod , Motor coordination , Pentylenetetrazol